Selye’s Generalised Adaptational Syndrome was examined in detail after the 1st World War in soldiers with very extreme cases of shell shock. 

This condition is particularly severe and can cause serious endocrinal disorder.  Diabetes is such a disorder as are many auto-immune diseases such as asthma, psoriasis etc  diseases often associated with the traditionally diagnosed psychoses. 

Anyone who has been subjected to severe stress over a long period could be suffering from such a condition and this would explain why the drugs do not work.  Liver enzymes such as the P450 group might be compromised by an undiagnosed condition such as Selye’s and if so the patient’s ability to metabolise the drugs might be similarly compromised.

Many soldiers returning from Afghanistan are drug refractive and many are suffering from PTSD which clearly needs examining.

PTSD originally was believed to have been caused by a single shocking event such as being in a disaster or being attacked however it is now widely recognised that sustained stressors can be even more damaging and disorder of extreme stress is the long term version of the one off event causing PTSD.

Many patients may have been misdiagnosed and consequently caught in a revolving door style trap.  The situation they are in is causing the stress and the stress is causing the psychotic behaviour classified as “dangerous”.  IT IS INCREDIBLY IMPORTANT THAT THEY ARE REASSESSED AND THAT THEIR ENDOCRINAL FUNCTION IS CHECKED OUT.

As far as my daughter is concerned I am suspicious as to why she was put on Metformine in the first place and intend to find out – how can someone just be put on 500mg a day  knowingly of contra indicated drugs which has gone on for so very long.  An investigation should be made as to what on earth is going on as harm could be caused to the patients as a result – my daughter is just one case – how many more are there when someone is not being properly assessed or treated and all along they could have a physical problem. 



Here are a number of papers implication hypothyroidism (endocrinal
disorder) with psychosis

Balldin J, Berggren U, Rybo E, et al. Treatment-resistant mania with
primary hypothyroidism: a case of recovery after levothyroxine. J Clin
Psychiatry. 1987;48:490-491.

Josephson AM, Mackenzie TB. Thyroid-induced mania in hypothyroid
patients. Br J Psychiatry. 1980;137:222-228.

Stancer HC, Persad E. Treatment of intractable rapid-cycling manic-
depressive disorder with levothyroxine. Clinical observations. Arch Gen

Asher R. Myxoedematous madness. Br Med J. 1949;2:555-562.

Heinrich TW, Grahm G. Hypothyroidism presenting as psychosis: myxedema
madness revisted. Prim Care Companion J Clin Psychiatry. 2003;5:260-

Lehrmann JA, Jain S. Myxedema psychosis with grade II hypothyroidism.
Gen Hosp Psychiatry. 2002;24:275-277.

Grozinsky-Glasberg S, Fraser A, Nahshoni E, et al. Thyroxine-
triiodothyronine combination therapy versus thyroxine monotherapy for
clinical hypothyroidism: meta-analysis of randomized controlled trials.
J Clin Endocrinol Metab. 2006;91:2592-2599.

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